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Recurrent miscarriage : what is it?
In France, recurrent miscarriage is defined as three consecutive first-trimester miscarriages (< 14 weeks' gestation) with the same partner. European guidelines (ESHRE) use a threshold of two miscarriages, not necessarily consecutive, to start investigations.
What causes recurrent miscarriage?
Here is a list of the different causes of recurrent miscarriage:
What should be done in the event of a recurrent miscarriage?
1. Progesterone supplementation in the first trimester reduces the risk of recurrent miscarriage in patients with recurrent miscarriages.
2. It is recommended that women with recurrent miscarriages and identified vitamin deficiency(s) be substituted with vitamins B6, B9, or B12.
3. If a cause has been identified, it should be treated: thyroid problem, pituitary anomalies, uterine anomaly, diabetes.
4. In the case of genetic anomalies, pre-implantation diagnosis may be considered.
5. It is recommended to prescribe aspirin + LMWH in women with recurrent miscarriage and antiphospholipid syndrome
6. It is not recommended to prescribe aspirin to prevent the recurrence of unexplained recurrent miscarriages.
Good to know - This article is provided for information purposes only and does not replace medical advice. The definition and the threshold for starting investigations vary between guidelines (French or European). After several miscarriages, an assessment may be offered: talk to your doctor or a gynaecologist.
